О некоторых направлениях дальнейшей автоматизации бетатронов

The novel ScaleMP vSMP architecture employs commodity x86-based servers with an InfiniBand network to assemble a large shared memory system at an attractive price point. We examine this combined hardware- and softwareapproach of a DSM system using both system-level kernel benchmarks as well as real-world application codes. We compare this architecture with traditional shared memory machines and elaborate on strategies to tune application codes parallelized with OpenMP on multiple levels. Finally we summarize the necessary conditions which a scalable application has to fulfill in order to profit from the full potential of the ScaleMP approach

International Space Station Columbus Payload SoLACES Degradation Assessment

SOLAR is a European Space Agency (ESA) payload deployed on the International Space Station (ISS) and located on the Columbus Laboratory. It is located on the Columbus External Payload Facility in a zenith location. The objective of the SOLAR payload is to study the Sun. The SOLAR payload consists of three instruments that allow for measurement of virtually the entire electromagnetic spectrum (17 nm to 100 um). The three payload instruments are SOVIM (SOlar Variable and Irradiance Monitor), SOLSPEC (SOLar SPECctral Irradiance measurements), and SolACES (SOLar AutoCalibrating Extreme UV/UV Spectrophotometers). The SolACES payload includes a set of 4 spectrometers that measure the solar EUV flux from 17 nm to 220 nm. One of these 4 spectrometers failed early on (before deployment). EUV data is important in understanding the solar dynamo. Also, EUV flux is the source of most of the ionization that produces the ionosphere plasma. Plasma production is important in understanding the ionosphere environment. The ionosphere conditions affect many subjects including spacecraft charging, dynamo processes, instabilities, and communications. The 3 remaining spectrometers have collected valuable data during the historically low solar cycle 24. Some of this data will be presented. A significant trend in degradation of the remaining SolACES spectrometers was observed towards the end of CY2010 (GMT 310) through mid CY 2011 (GMT 132). The Principle Investigators of SolACES initiated a Mission Evaluation Room (MER) Chit to request an investigation of the degradation in CY 2011 (GMT 230). The Boeing Space Environments team was asked to respond to the ESA initiated MER Chit request to investigate the cause of the degradation. This paper will discuss the findings of that investigation

International Space Station Columbus Payload SoLACES Degradation Assessment

SOLAR is a European Space Agency (ESA) payload deployed on the International Space Station (ISS) and located on the Columbus Laboratory. It is located on the Columbus External Payload Facility in a zenith location. The objective of the SOLAR payload is to study the Sun. The SOLAR payload consists of three instruments that allow for measurement of virtually the entire electromagnetic spectrum (17 nm to 2900 nm). The three payload instruments are SOVIM (SOlar Variable and Irradiance Monitor), SOLSPEC (SOLar SPECctral Irradiance measurements), and SolACES (SOLar AutoCalibrating Extreme UV/UV Spectrophotometers)

Chromatin accessibility maps of chronic lymphocytic leukemia identify subtypespecific epigenome signatures and associated transcription regulatory networks

Chronic lymphocytic leukemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for studying epigenome deregulation in CLL, we established genome-wide chromatin accessibility maps for 88 CLL samples from 55 patients using the ATAC-seq assay. These data were further complemented by ChIPmentation and RNA-seq profiling in ten samples. Based on this dataset, we devised and applied a bioinformatic method that links chromatin profiles to clinical annotations. Our analysis identified sample-specific variation on top of a shared core of CLL regulatory regions. IGHV mutation status – which distinguishes the two major subtypes of CLL – was accurately predicted by the chromatin profiles, and gene regulatory networks inferred for IGHV-mutated vs. IGHV-unmutated samples identified characteristic regulatory differences between these two disease subtypes. In summary, we found widespread heterogeneity in the CLL chromatin landscape, established a community resource for studying epigenome deregulation in leukemia, and demonstrated the feasibility of chromatin accessibility mapping in cancer cohorts and clinical research

Absolute EUV reflectivity measurements using a broadband high-harmonic source and an in situ single exposure reference scheme

We present a tabletop setup for extreme ultraviolet (EUV) reflection spectroscopy in the spectral range from 40 to 100 eV by using high-harmonic radiation. The simultaneous measurements of reference and sample spectra with high energy resolution provide precise and robust absolute reflectivity measurements, even when operating with spectrally fluctuating EUV sources. The stability and sensitivity of EUV reflectivity measurements are crucial factors for many applications in attosecond science, EUV spectroscopy, and nano-scale tomography. We show that the accuracy and stability of our in situ referencing scheme are almost one order of magnitude better in comparison to subsequent reference measurements. We demonstrate the performance of the setup by reflective near-edge x-ray absorption fine structure measurements of the aluminum L2/3 absorption edge in α-Al2O3 and compare the results to synchrotron measurements

Chancengerechtigkeit durch Bildung – Chancengerechtigkeit in der Bildung (Auszug)

Der hier mit freundlicher Genehmigung des AWO Bundesverbands abgedruckte Text ist ein Auszug aus der Broschüre: Arbeiterwohlfahrt Bundesverband (Hrsg.): Standpunkte 2006. Chancengerechtigkeit durch Bildung – Chancengerechtigkeit in der Bildung, Bonn 2006. Unser Bildungssystem für die Kinder im Alter von 6 bis 16 Jahren wird den Herausforderungen der Zukunft nicht gerecht. Ein Umsteuern ist dringend notwendig, da ohne Bildung der Wandel in die Wissensgesellschaft nicht zu bewältigen ist. Bildung, Qualifikation und Kompetenzen und das Erlernen von Diskurs- und Konfliktfähigkeit entscheiden über die beruflichen und gesellschaftlichen Chancen eines jeden Menschen und davon abhängig über seine Zukunftschancen. Bildung bedeutet Entwicklung der Persönlichkeit, der Identität. Bildung bedeutet aber auch, die gemeinschaftsfähige Persönlichkeit zu gestalten. Und somit bekommt Bildung gerade in der Lebensphase der 6- bis 16-Jährigen über die eher traditionelle Dimension hinaus auch einen emanzipatorischen Charakter. Wenn Bildung also für den Einzelnen diese entscheidende Rolle spielt, dann bekommt die öffentliche Verantwortung für dieses Bildungswesen eine ganz zentrale Bedeutung. (DIPF/Orig.

Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL

The Bruton tyrosine kinase (BTK) inhibitor ibrutinib provides effective treatment for patients with chronic lymphocytic leukemia (CLL), despite extensive heterogeneity in this disease. To define the underlining regulatory dynamics, we analyze high-resolution time courses of ibrutinib treatment in patients with CLL, combining immune-phenotyping, single-cell transcriptome profiling, and chromatin mapping. We identify a consistent regulatory program starting with a sharp decrease of NF-kappa B binding in CLL cells, which is followed by reduced activity of lineage-defining transcription factors, erosion of CLL cell identity, and acquisition of a quiescence-like gene signature. We observe patient-to-patient variation in the speed of execution of this program, which we exploit to predict patient-specific dynamics in the response to ibrutinib based on the pre-treatment patient samples. In aggregate, our study describes time-dependent cellular, molecular, and regulatory effects for therapeutic inhibition of B cell receptor signaling in CLL, and it establishes a broadly applicable method for epigenome/transcriptome-based treatment monitoring